Regulation of the encapsulation, protection, and controlled release properties of naringin by sodium alginate oxidized hydrogel as a steady-state delivery system.

以海藻酸钠氧化水凝胶为稳态递送系统，调控柚皮苷的包封、保护和控释性能

Shuxian Bai, Lei Chen, Hui Teng, Hesham El-Seedi, Junyan Yu, Chao Ai (2026) Regulation of the encapsulation, protection, and controlled release properties of naringin by sodium alginate oxidized hydrogel as a steady-state delivery system. Front Nutr (IF: 5.1) 2 区 13 1809564

Abstract

Addressing the application challenges of low oral bioavailability and poor chemical stability associated with the citrus flavonoid naringin, hydrogels featuring unique three-dimensional network structures have garnered significant attention in the field of bioactive compound delivery.In this study, a natural polysaccharide hydrogel delivery system based on dynamic imine bonds was designed and constructed. By regulating the oxidation degree of oxidized sodium alginate (OSA), hydrogels with distinct pore sizes were engineered to achieve stable encapsulation and controlled release of naringin. Dynamic covalent crosslinking between the aldehyde groups on OSA chains and the amino groups of carboxymethyl chitosan (CMC) endowed the hydrogels with exceptional adaptability.Research indicates that increasing the oxidation state of OSA can form a denser cross-linked network, thereby significantly regulating the swelling behavior, biodegradation rate, and drug release kinetics of hydrogels. Among these, 6OSA-Hy exhibits the most ideal sustained-release properties, enabling continuous and controlled release of naringin in simulated environments. In vitro cell experiments confirmed that this delivery system exhibits excellent biocompatibility, and its released active components effectively promote cell migration, with the 6OSA-Hy group achieving a scratch closure rate of 43.5%.The above studies demonstrate that the hydrogel system developed in this research provides a sustained-release stabilization strategy for enhancing the delivery of bioactive compounds such as naringin. This approach holds potential for improving bioavailability and is expected to find applications in the development of functional foods and nutritional supplements.Copyright © 2026 Bai, Chen, Teng, El-Seedi, Yu and Ai.

针对柑橘类黄酮柚皮苷口服生物利用度低和化学稳定性差等应用难题，具有独特三维网络结构的水凝胶在生物活性化合物递送领域引起了广泛关注。本研究设计并构建了一种基于动态亚胺键的天然多糖水凝胶递送系统。通过调控氧化海藻酸钠（OSA）的氧化程度，制备了具有不同孔径的水凝胶，实现了柚皮苷的稳定包封和可控释放。OSA链上的醛基与羧甲基壳聚糖（CMC）的氨基之间的动态共价交联赋予了水凝胶优异的适应性。研究表明，提高OSA的氧化程度可以形成更致密的交联网络，从而显著调控水凝胶的溶胀行为、生物降解速率和药物释放动力学。其中，6OSA-Hy展现出最理想的缓释性能，能够在模拟环境中实现柚皮苷的持续可控释放。体外细胞实验证实，该递送系统具有优异的生物相容性，其释放的活性成分能够有效促进细胞迁移，6OSA-Hy组的划痕愈合率达到43.5%。以上研究表明，本研究开发的水凝胶系统为增强柚皮苷等生物活性化合物的递送提供了一种缓释稳定策略。该方法具有提高生物利用度的潜力，有望应用于功能性食品和营养补充剂的开发。版权所有 © 2026 Bai, Chen, Teng, El-Seedi, Yu and Ai.